Custom Enzymes and Inhibitors
Selleck Chemical LLC Talazoparib (BMN 673) 10mg 1207456-01-6 LT-673
Talazoparib (BMN 673, LT-673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Urease from Canavalia ensiformis
Urease from Canavalia ensiformis (Jack bean), Type III, glycerol solution, 500-800 units/mL, CAS Number 9002-13-5, MDL number MFCD00070858
Sigma Aldrich Fine Chemicals Biosciences Protease from Streptomyces griseus Type XIV, >=3.5 units/mg solid, powder | 9036-06-0 | MFCD00132092 | 100MG
Protease from Streptomyces griseus Type XIV, >=3.5 units/mg solid, powder | 9036-06-0 | MFCD00132092 | 100MG
Apexbio Technology LLC Esomeprazole Sodium, 10mg. Cas: 161796-78-7 MFCD: MFCD07802816. Proton pump inhibitor
Esomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor. 161796-78-7. MFCD07802816
Selleck Chemical LLC PCI-34051 10mg 950762-95-5
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tivozanib (AV-951) 5mg 475108-18-0 KRN-951
Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Elesclomol (STA-4783) 50mg 488832-69-5
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Luminespib (NVP-AUY922) 5mg 747412-49-3 AUY-922
Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90?/? with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1R? protein and results in growth inhibition, autophagy and apoptosis. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC KU-60019 10mg 925701-49-1
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC NSC 146109 (hydrochloride) | 59474-01-0 | MFCD09878281 | 99.6% | 316.85 g/mol | C17H17ClN2S | 5 MG
NSC 146109 hydrochloride is a research-grade small molecule that activates p53-dependent transcription and induces apoptosis in relevant cell models. Supplied as the hydrochloride salt, it is used in biochemical and cell-based assays to study p53 pathway modulation, MDMX targeting, and tumor suppressor activation.
- High purity solid, white to yellow, suitable for research use.
- Hydrochloride salt provides improved solubility for in vitro studies.
- Demonstrated p53 activation and pro-apoptotic activity in cellular assays.
- Available in small milligram quantities and ready-made DMSO solutions.
- Storage recommendations support refrigerated and frozen stability.
Medchemexpress LLC Mc-val-cit-pab-indibulin | 2055896-95-0 | MFCD32201121 | 95.8% | 945.49 g/mol | C50H55ClN9O8+ | 50 MG
MC-Val-Cit-PAB-Indibulin is an antibody-drug conjugate (ADC) drug-linker conjugate in which the tubulin inhibitor indibulin is attached via a cleavable MC-Val-Cit-PAB linker. It is intended for research use in ADC development and preclinical studies.
- Provides an indibulin payload linked through a protease-cleavable Val-Cit spacer
- Offers a maleimidocaproyl (MC) reactive handle for thiol conjugation
- Suitable for antibody-drug conjugate synthesis and preclinical evaluation
- Reported purity suitable for research applications
- Available in multiple milligram-scale package sizes for development needs
Biochain Institute Inc Placenta Ribonuclease Inhibitor, 5000 units/PK
BioChain offers the most used enzymes in molecular biology and biochemistry, such as DNase I, RNase A, with premium quality and at the most competitive price.
Abcam A 83-01, ALK4, 5 and 7 kinase inhibitor, 1MG
MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC₅₀ values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement